GFR (Creatinine clearance)
PCreat:
Age: years
Weight:
Gender: Male
Female
Race: African American
Other

Cockcroft:
ml/min
MDRD:
ml/min
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Warning! This site it targeted at medical professionals and medical students only. No claims are made of the accuracy of this calculator. Always confirm the results of this calculator before use. Never use the results of this calculator alone as a guide to patient care, always trust your clinical judgement. The authors of this calculator shall not be liable for damages resulting from use of this calculator.

This calculator calculates the creatinine clearance using the Cockcroft-Gault and MDRD (Modification of Diet in Renal Disease) formula, to approximate the kidney glomerular filtration rate (GFR):

Cockcroft-Gault formula in mg/dl:

GFRcockcroft = ((140-age) * mass (kg) [ * 0.85 if female ]) / 72 * serum creatinine (mg/dl)

Cockcroft-Gault formula in μmol/l:

GFRcockcroft = ((140-age) * mass (kg) [ * 1.23 if male ] [ * 1.04 if female ]) / serum creatinine (μmol/l)

MDRD formula in mg/dl:

GFRmdrd = 186 * serum creatinine (mg/dl)^-1.154 * age^-0.203 [ * 1.210 if african-american ] [ * 0.742 if female ]

MDRD formula in μmol/l:

GFRmdrd = 32788 * serum creatinine (μmol/l)^-1.154 * age^-0.203 [ * 1.210 if african-american ] [ * 0.742 if female ]

The inulin clearance estimates the glomerular function more accurately, since it is fully filtered and neither reabsorbed nor secreted in the tubular system. Note that inulin clearance is not sensitive for early renal disease due to hyperfiltration in the remaining nephrons. After administering inulin, the serum inulin concentration is measured. Urine is analyzed for inulin concentration and measured for volume. Complete urine collection is of crucial importance for the determination of inulin clearance. The inulin clearance slightly overestimates the glomerular function when compared to the MDRD formula.

Inulin clearance formula:

GFR = U * V / P

A GFR below 60 ml/min or a rapid decline in GFR indicates possible renal disease.

References: